GrippeEspagneV1, Main, Exploration, bibRecord, 000140

Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children.

Identifieur interne : 000140 ( Main/Exploration ); précédent : 000139; suivant : 000141

Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children.

Auteurs : Cristina Calvo [Espagne] ; María Luz García-García [Espagne] ; Francisco Pozo [Espagne] ; Daniel Carballo [Espagne] ; Eduardo Martínez-Monteserín [Espagne] ; Inmaculada Casas [Espagne]

Source :

Journal of medical virology [ 1096-9071 ] ; 2016.

RBID : pubmed:27124519

Descripteurs français

English descriptors

KwdEn :
- Adolescent (MeSH), Child (MeSH), Child, Preschool (MeSH), Coinfection (diagnosis), Coinfection (epidemiology), Coinfection (virology), Female (MeSH), Hospitalization (statistics & numerical data), Human bocavirus (isolation & purification), Human bocavirus (pathogenicity), Humans (MeSH), Incidence (MeSH), Infant (MeSH), Male (MeSH), Parvoviridae Infections (complications), Parvoviridae Infections (diagnosis), Parvoviridae Infections (epidemiology), Parvoviridae Infections (virology), Picornaviridae Infections (epidemiology), Picornaviridae Infections (virology), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Prospective Studies (MeSH), Respiratory Syncytial Virus Infections (epidemiology), Respiratory Syncytial Virus Infections (virology), Respiratory Syncytial Virus, Human (isolation & purification), Respiratory Tract Infections (diagnosis), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (virology), Rhinovirus (isolation & purification), Seasons (MeSH), Spain (epidemiology), Virus Diseases (diagnosis), Virus Diseases (epidemiology), Virus Diseases (virology), Viruses (classification), Viruses (isolation & purification).
MESH :
- classification : Viruses.
- complications : Parvoviridae Infections.
- diagnosis : Coinfection, Parvoviridae Infections, Pneumonia, Viral, Respiratory Tract Infections, Virus Diseases.
- epidemiology : Coinfection, Parvoviridae Infections, Picornaviridae Infections, Pneumonia, Viral, Respiratory Syncytial Virus Infections, Respiratory Tract Infections, Spain, Virus Diseases.
- isolation & purification : Human bocavirus, Respiratory Syncytial Virus, Human, Rhinovirus, Viruses.
- pathogenicity : Human bocavirus.
- statistics & numerical data : Hospitalization.
- virology : Coinfection, Parvoviridae Infections, Picornaviridae Infections, Respiratory Syncytial Virus Infections, Respiratory Tract Infections, Virus Diseases.
- Adolescent, Child, Child, Preschool, Female, Humans, Incidence, Infant, Male, Prospective Studies, Seasons.

Abstract

The human bocavirus (hBoV) has been identified in respiratory infections in children in a large number of studies. Despite this, the pathogenic role of the HBoV is under discussion. The main objectives of the study were: to determine the incidence of HBoV in hospitalized children; to describe the main clinical features of the positive children; and to compare the data with those from other viral infections in the same population. A prospective study was performed between 2005 and 2013 including children up to 14-year old with respiratory infection admitted to the Severo Ochoa Hospital (Spain). Nasopharyngeal aspirates were taken from 3,275 patients and were tested for HBoV and other 15 respiratory viruses by RT-nested PCR. HBoV was detected in 319 patients (9.9%); 80 cases as a single pathogen, and 239 cases (75%) as coinfections with other viruses. The HBoV was the fourth most common virus detected, behind respiratory syncytial virus (39.8%), rhinovirus (30.6%), and adenovirus (15%). The most common clinical diagnosis, in cases that HBoV was detected as a single pathogen was asthma exacerbation followed by pneumonia. A seasonal distribution was shown, with higher positivity rates in December and January. Children affected by HBoV were older than children infected by other viruses. Differences in terms of clinical diagnosis were found, bronchiolitis diagnosis was lower compared with the other viruses, and HBoV was associated with diagnosis of pneumonia, with increased use of antibiotics (41.8%), and radiographic infiltrates (47%). These findings could suggest a pathogenic role of HBoV in respiratory infections in children under 14 years of age. J. Med. Virol. 88:2052-2058, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

DOI: 10.1002/jmv.24562
PubMed: 27124519
PubMed Central: PMC7166349

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00135
to stream Main, to step Curation: 000135

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Coinfection (diagnosis)</term>
<term>Coinfection (epidemiology)</term>
<term>Coinfection (virology)</term>
<term>Female (MeSH)</term>
<term>Hospitalization (statistics & numerical data)</term>
<term>Human bocavirus (isolation & purification)</term>
<term>Human bocavirus (pathogenicity)</term>
<term>Humans (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Male (MeSH)</term>
<term>Parvoviridae Infections (complications)</term>
<term>Parvoviridae Infections (diagnosis)</term>
<term>Parvoviridae Infections (epidemiology)</term>
<term>Parvoviridae Infections (virology)</term>
<term>Picornaviridae Infections (epidemiology)</term>
<term>Picornaviridae Infections (virology)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Prospective Studies (MeSH)</term>
<term>Respiratory Syncytial Virus Infections (epidemiology)</term>
<term>Respiratory Syncytial Virus Infections (virology)</term>
<term>Respiratory Syncytial Virus, Human (isolation & purification)</term>
<term>Respiratory Tract Infections (diagnosis)</term>
<term>Respiratory Tract Infections (epidemiology)</term>
<term>Respiratory Tract Infections (virology)</term>
<term>Rhinovirus (isolation & purification)</term>
<term>Seasons (MeSH)</term>
<term>Spain (epidemiology)</term>
<term>Virus Diseases (diagnosis)</term>
<term>Virus Diseases (epidemiology)</term>
<term>Virus Diseases (virology)</term>
<term>Viruses (classification)</term>
<term>Viruses (isolation & purification)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Bocavirus humain (isolement et purification)</term>
<term>Bocavirus humain (pathogénicité)</term>
<term>Co-infection (diagnostic)</term>
<term>Co-infection (virologie)</term>
<term>Co-infection (épidémiologie)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Hospitalisation (statistiques et données numériques)</term>
<term>Humains (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Infections de l'appareil respiratoire (diagnostic)</term>
<term>Infections de l'appareil respiratoire (virologie)</term>
<term>Infections de l'appareil respiratoire (épidémiologie)</term>
<term>Infections à Parvoviridae (complications)</term>
<term>Infections à Parvoviridae (diagnostic)</term>
<term>Infections à Parvoviridae (virologie)</term>
<term>Infections à Parvoviridae (épidémiologie)</term>
<term>Infections à Picornaviridae (virologie)</term>
<term>Infections à Picornaviridae (épidémiologie)</term>
<term>Infections à virus respiratoire syncytial (virologie)</term>
<term>Infections à virus respiratoire syncytial (épidémiologie)</term>
<term>Maladies virales (diagnostic)</term>
<term>Maladies virales (virologie)</term>
<term>Maladies virales (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Nourrisson (MeSH)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Rhinovirus (isolement et purification)</term>
<term>Saisons (MeSH)</term>
<term>Virus (classification)</term>
<term>Virus (isolement et purification)</term>
<term>Virus respiratoire syncytial humain (isolement et purification)</term>
<term>Études prospectives (MeSH)</term>
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<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parvoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coinfection</term>
<term>Parvoviridae Infections</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Tract Infections</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Co-infection</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections à Parvoviridae</term>
<term>Maladies virales</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coinfection</term>
<term>Parvoviridae Infections</term>
<term>Picornaviridae Infections</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Syncytial Virus Infections</term>
<term>Respiratory Tract Infections</term>
<term>Spain</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Human bocavirus</term>
<term>Respiratory Syncytial Virus, Human</term>
<term>Rhinovirus</term>
<term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Bocavirus humain</term>
<term>Rhinovirus</term>
<term>Virus</term>
<term>Virus respiratoire syncytial humain</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Human bocavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Bocavirus humain</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Co-infection</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections à Parvoviridae</term>
<term>Infections à Picornaviridae</term>
<term>Infections à virus respiratoire syncytial</term>
<term>Maladies virales</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coinfection</term>
<term>Parvoviridae Infections</term>
<term>Picornaviridae Infections</term>
<term>Respiratory Syncytial Virus Infections</term>
<term>Respiratory Tract Infections</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Co-infection</term>
<term>Espagne</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections à Parvoviridae</term>
<term>Infections à Picornaviridae</term>
<term>Infections à virus respiratoire syncytial</term>
<term>Maladies virales</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Infant</term>
<term>Male</term>
<term>Prospective Studies</term>
<term>Seasons</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Adolescent</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Infections à Parvoviridae</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Saisons</term>
<term>Virus</term>
<term>Études prospectives</term>
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<front><div type="abstract" xml:lang="en">The human bocavirus (hBoV) has been identified in respiratory infections in children in a large number of studies. Despite this, the pathogenic role of the HBoV is under discussion. The main objectives of the study were: to determine the incidence of HBoV in hospitalized children; to describe the main clinical features of the positive children; and to compare the data with those from other viral infections in the same population. A prospective study was performed between 2005 and 2013 including children up to 14-year old with respiratory infection admitted to the Severo Ochoa Hospital (Spain). Nasopharyngeal aspirates were taken from 3,275 patients and were tested for HBoV and other 15 respiratory viruses by RT-nested PCR. HBoV was detected in 319 patients (9.9%); 80 cases as a single pathogen, and 239 cases (75%) as coinfections with other viruses. The HBoV was the fourth most common virus detected, behind respiratory syncytial virus (39.8%), rhinovirus (30.6%), and adenovirus (15%). The most common clinical diagnosis, in cases that HBoV was detected as a single pathogen was asthma exacerbation followed by pneumonia. A seasonal distribution was shown, with higher positivity rates in December and January. Children affected by HBoV were older than children infected by other viruses. Differences in terms of clinical diagnosis were found, bronchiolitis diagnosis was lower compared with the other viruses, and HBoV was associated with diagnosis of pneumonia, with increased use of antibiotics (41.8%), and radiographic infiltrates (47%). These findings could suggest a pathogenic role of HBoV in respiratory infections in children under 14 years of age. J. Med. Virol. 88:2052-2058, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.</div>
</front>
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<Day>07</Day>
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<Month>04</Month>
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<Issue>12</Issue>
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<Title>Journal of medical virology</Title>
<ISOAbbreviation>J. Med. Virol.</ISOAbbreviation>
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<ArticleTitle>Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children.</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.24562</ELocationID>
<Abstract><AbstractText>The human bocavirus (hBoV) has been identified in respiratory infections in children in a large number of studies. Despite this, the pathogenic role of the HBoV is under discussion. The main objectives of the study were: to determine the incidence of HBoV in hospitalized children; to describe the main clinical features of the positive children; and to compare the data with those from other viral infections in the same population. A prospective study was performed between 2005 and 2013 including children up to 14-year old with respiratory infection admitted to the Severo Ochoa Hospital (Spain). Nasopharyngeal aspirates were taken from 3,275 patients and were tested for HBoV and other 15 respiratory viruses by RT-nested PCR. HBoV was detected in 319 patients (9.9%); 80 cases as a single pathogen, and 239 cases (75%) as coinfections with other viruses. The HBoV was the fourth most common virus detected, behind respiratory syncytial virus (39.8%), rhinovirus (30.6%), and adenovirus (15%). The most common clinical diagnosis, in cases that HBoV was detected as a single pathogen was asthma exacerbation followed by pneumonia. A seasonal distribution was shown, with higher positivity rates in December and January. Children affected by HBoV were older than children infected by other viruses. Differences in terms of clinical diagnosis were found, bronchiolitis diagnosis was lower compared with the other viruses, and HBoV was associated with diagnosis of pneumonia, with increased use of antibiotics (41.8%), and radiographic infiltrates (47%). These findings could suggest a pathogenic role of HBoV in respiratory infections in children under 14 years of age. J. Med. Virol. 88:2052-2058, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.</AbstractText>
<CopyrightInformation>Published 2016. This article is a U.S. Government work and is in the public domain in the USA.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Calvo</LastName>
<ForeName>Cristina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Severo Ochoa Hospital, Leganés, Madrid, Spain. ccalvorey@ono.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University Alfonso X el Sabio, Madrid, Spain. ccalvorey@ono.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García-García</LastName>
<ForeName>María Luz</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Severo Ochoa Hospital, Leganés, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University Alfonso X el Sabio, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pozo</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carballo</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>University Alfonso X el Sabio, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martínez-Monteserín</LastName>
<ForeName>Eduardo</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>University Alfonso X el Sabio, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Casas</LastName>
<ForeName>Inmaculada</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>05</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Med Virol</MedlineTA>
<NlmUniqueID>7705876</NlmUniqueID>
<ISSNLinking>0146-6615</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060085" MajorTopicYN="N">Coinfection</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056661" MajorTopicYN="N">Human bocavirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010322" MajorTopicYN="N">Parvoviridae Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010850" MajorTopicYN="N">Picornaviridae Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018357" MajorTopicYN="N">Respiratory Syncytial Virus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018113" MajorTopicYN="N">Respiratory Syncytial Virus, Human</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012229" MajorTopicYN="N">Rhinovirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">coinfections</Keyword>
<Keyword MajorTopicYN="Y">human bocavirus</Keyword>
<Keyword MajorTopicYN="Y">respiratory infections</Keyword>
<Keyword MajorTopicYN="Y">viral infections</Keyword>
</KeywordList>
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<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Communauté de Madrid</li>
</region>
<settlement><li>Madrid</li>
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<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name>
</region>
<name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name>
<name sortKey="Carballo, Daniel" sort="Carballo, Daniel" uniqKey="Carballo D" first="Daniel" last="Carballo">Daniel Carballo</name>
<name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name>
<name sortKey="Garcia Garcia, Maria Luz" sort="Garcia Garcia, Maria Luz" uniqKey="Garcia Garcia M" first="María Luz" last="García-García">María Luz García-García</name>
<name sortKey="Garcia Garcia, Maria Luz" sort="Garcia Garcia, Maria Luz" uniqKey="Garcia Garcia M" first="María Luz" last="García-García">María Luz García-García</name>
<name sortKey="Martinez Monteserin, Eduardo" sort="Martinez Monteserin, Eduardo" uniqKey="Martinez Monteserin E" first="Eduardo" last="Martínez-Monteserín">Eduardo Martínez-Monteserín</name>
<name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name>
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Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children.

Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children.

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